UNIVERSITY OF VIRGINIA RESEARCHERS FOUND THAT PRIOR ANTIBIOTIC USE IMPAIRED SUBSEQUENT IMMUNE CELL FUNCTION IN CHILDREN. They first noticed that amebic colitis, a potentially fatal illness, was more severe in Bangladeshi children who had altered gut bacteria, usually occurring from prior antibiotic use. They then studied the problem in mice and found that antibiotic use impaired the ability of white blood cells to fight infection. The message is to only use antibiotics when they are necessary because their use can actually make subsequent infections worse.
NSAID or Non Steroidal Anti-Inflammatory Drug (EG Motrin, Aleve, Meloxicam) Use Before Rotator Cuff Surgery Increases Failures
Although the general public is generally not aware of it, it is well established in the medical literature that NSAID drugs interfere with healing. For this reason in particular I never use them when I perform reparative surgery where they might compromise the surgical repair. This has been well shown in various animal studies but there have few studies in humans where it has been looked at. However in a new study from Norway the use of NSAIDs before surgery was correlated with a greater chance of failure afterward. This is quite significant in that the drug use did not have to be during the period of healing to impair healing later. The most common drugs in this class are Ibuprofen (motrin, advil), Naproxen (Aleve), and Aspirin over the counter and Diclofenac, Meloxicam and Celebrex by prescription.
A few weeks ago I saw a 90 year old retired doctor, whose physician daughter brought him in, with one completely ruptured Achilles tendon and one partially ruptured. Usually these require significant trauma – which he did not have. What was the cause? In his case the tendon ruptures were the result of his having taken Cipro, a Fluoroquinolone antibiotic for an infection. In fact such tendon injuries, and other complications with use of these antibiotics are relatively common so that the FDA on 7/26/2016 wrote:
A recent study from the US Naval Academy has shown that the use of NSAIDs (nonsteroidal anti-inflammatory drugs) such as advil, motrin, aleve, diclofenac and meloxicam around the time of surgery or afterward.