This Amazing Result is an amazing story in and of itself. And it is also a portent of even better results that should be coming in the future. While this story concerns results at USC, the same study is being conducted at multiple sites including Rush University in Chicago under eminent spine surgeon Richard Fessler MD. Click here to read.
Health Care News
It is well established that Non-Steroidal Anti-inflammatory Drugs (NSAIDs) such as ibuprofen (motrin, advil), naproxen (aleve), aspirin, celebrex, diclofenac, and meloxicam interfere with the healing of ligaments, bones, tendons and other connective tissue. For this reason Orthopaedic Surgeons are cautious in their use after reconstructive surgery and in other applications - although there are few clinical studies showing the effect of NSAIDs on outcomes. However, a recent paper entitled Predictors of Revision Surgery After Anterior Cruciate Ligament Reconstruction from the US Navy published in the American Journal of Sportsmedicine found a significant correlation with the use of NSAIDs and an increased rate of revision, i.e. failure, after ACL reconstruction. This held true for both so-called COX-1 NSAIDs, the vast majority available, and also COX-2 NSAIDs which include Celebrex and Meloxicam. The authors write “Increased odds of revision surgery among active-duty personnel were associated with the perioperative use of NSAIDs and COX-2 inhibitors.” This reinforces the conclusion found in one of the few other papers to look at this topic The effect of ketorolac on anteroposterior knee laxity after anterior cruciate ligament reconstruction. where it was found that “The use of ketorolac during bone-patellar tendon autograft ACL reconstruction was associated with increased AP laxity at 6 weeks postoperatively.”
Stem cell therapy is being used in every area of clinical medicine. The general area of autoimmune disorders is one of the most promising. While the tissue regenerative aspects of stem cell therapy garner the most attention, their immune-modulatory capabilities are at least as important. For reasons that are only partially clear, diabetes is becoming increasingly common. It requires strict long term care to minimize its effects including frequent insulin injections and often insulin pumps. These are time consuming, expensive, and limiting to patients. And they do no completely control its long term effects. Diabetes is a leading cause of both blindness and kidney disease for example. There are many areas of ongoing stem cell research to treat Diabetes. However a 2013 paper entitled "Targeting insulin resistance in type 2 diabetes via immune modulation of cord blood-derived multipotent stem cells (CB-SCs) in stem cell educator therapy: phase I/II clinical trial" by Yong Zhao et al. showed remarkable results from a brilliant and completely different use of stem cell therapy than any prior studies.
Anterior cruciate ligament reconstruction with a novel porcine xenograft: the initial Italian experience Anterior cruciate ligament reconstruction and service in the British Army Long-Term Examination of Bone Mineral Density in the Calcanei After Anterior Cruciate Ligament Reconstruction in Adolescents and Matched Adult Controls