Dr Prodromos Stem Cell/PRP Blog – September 2015

Dr Prodromos Stem Cell/PRP Blog – September 2015

Stem Cells improve results in heart attack patients PRP better than cortisone for plantar fasciitis PRP promotes cartilage growth, and does so via ADP PRP helps patients with lumbar disk disease

  • Stem Cells improve results in heart attack patients
  • PRP better than cortisone for plantar fasciitis
  • PRP promotes cartilage growth, and does so via ADP
  • PRP helps patients with lumbar disk disease

STEM CELLS IMPROVE RESULTS IN HEART ATTACK PATIENTS

Circ Res. 2015 Aug 28;117(6):558-75. doi: 10.1161/CIRCRESAHA.114.304792. Epub 2015 Jul 9.

Adult Bone Marrow Cell Therapy for Ischemic Heart Disease: Evidence and Insights From Randomized Controlled Trials.

Afzal MR1, Samanta A1, Shah ZI1, Jeevanantham V1, Abdel-Latif A1, Zuba-Surma EK1, Dawn B1.

“CONCLUSIONS: Transplantation of adult BMCs improves LV ejection fraction, reduces infarct size, and ameliorates remodeling in patients with ischemic heart disease. These effects are upheld in the analyses of studies using magnetic resonance imaging and also after excluding studies with discrepant reporting of outcomes. BMC transplantation may also reduce the incidence of death, recurrent myocardial Infarction, ventricular arrhythmia, and cerebrovascular accident during follow-up.”

This meta-analysis provides evidence of the striking benefits of mesenchymal stem cells in the treatment of ischemic heart disease, “heart attack” patients.

PRP BETTER THAN CORTISONE FOR PLANTAR FASCIITIS

Foot (Edinb). 2015 Aug 22. pii: S0958-2592(15)00083-8. doi: 10.1016/j.foot.2015.08.006. [Epub ahead of print]

Platelet rich plasma versus corticosteroid injection for plantar fasciitis: A comparative study.

Jain K1, Murphy PN2, Clough TM3. 26362235

“PRP is as effective as Steroid injection at achieving symptom relief at 3 and 6 months after injection, for the treatment of plantar fasciitis, but unlike Steroid, its effect does not wear off with time. At 12 months, PRP is significantly more effective than Steroid, making it better and more durable than cortisone injection”

This is an interesting study since it describes the effect of platelet rich plasma on fibrous tissue which is a less common application than its use in tendons and ligaments. As with applications elsewhere, one of the main benefits of PRP versus a steroid is that the effects tend to be longer lasting

PRP PROMOTES CARTILAGE GROWTH, AND DOES SO VIA ADP

Foot (Edinb). 2015 Aug 22. pii: S0958-2592(15)00083-8. doi: 10.1016/j.foot.2015.08.006. [Epub ahead of print]

Platelet rich plasma versus corticosteroid injection for plantar fasciitis: A comparative study.

Jain K1, Murphy PN2, Clough TM3. 26362235

“PRP is as effective as Steroid injection at achieving symptom relief at 3 and 6 months after injection, for the treatment of plantar fasciitis, but unlike Steroid, its effect does not wear off with time. At 12 months, PRP is significantly more effective than Steroid, making it better and more durable than cortisone injection”

This is an interesting study since it describes the effect of platelet rich plasma on fibrous tissue which is a less common application than its use in tendons and ligaments. As with applications elsewhere, one of the main benefits of PRP versus a steroid is that the effects tend to be longer lasting

PRP HELPS PATIENTS WITH LUMBAR DISK DISEASE

Lumbar Intradiscal Platelet Rich Plasma (PRP) Injections: A Prospective, Double-blind, Randomized Controlled Study.

Tuakli-Wosornu YA1, Terry A1, Boachie-Adjei K1, Harrison JR1, Gribbin CK1, LaSalle EE1, Nguyen JT2, Solomon JL3, Lutz GE4. pmid 26314234

“Participants who received intradiscal PRP showed significant improvements in FRI, NRS Best Pain, and NASS patient satisfaction scores over eight weeks when compared to controls. Those who received PRP maintained significant improvements in FRI scores through at least one year of follow-up.”

While stem cells have received much attention for intra-discal therapy, PRP has been shown to be quite effective, and is often combined with stem cells for treatment.

  • American Academy of Regenerative Medicine
  • American Board of Regenerative Medicine
  • aossm
  • isakos
  • Rush University Medical Center
  • aana
  • aaos
  • esska
  • cartilage